Washington University School of Medicine is one of the world’s leading medical research institutions. During the fiscal year ending June 30, 2013. $462.5 million of research funding was awarded to the School of Medicine with $338.5 million from Federal sources. The School of Medicine possesses a rich tradition of interdisciplinary collaboration, fostering an exciting environment in which basic science and clinical medicine are very closely connected. The School’s faculty is among the most prestigious in the nation. Seventeen Nobel laureates have been associated with the School. There are thirteen members of the National Academy of Sciences (two associated with this BIRCWH Program, Drs. Hultgren and Yokoyama), twenty members of the Institute of Medicine (three associated with this BIRCWH Program, Drs. Colditz, Moley, and Yokoyama). Ninety-seven faculty members hold individual career development awards from the National Institutes of Health (NIH), and an additional fifty-one faculty members hold career development awards from non-federal agencies. Thirteen investigators have NIH MERIT status, and four scientists are Howard Hughes Medical Institute investigators (one associated with this BIRCWH Program, Dr. Yokoyama). World-class facilities support faculty research, including core facilities for DNA sequencing and genetic analysis, biostatistics, clinical research, transgenic support, higher brain function studies, cell and tissue culture, morphology, protein and lipid analysis, molecular design, information management, monoclonal antibody production, mass spectrometry, nuclear magnetic resonance spectroscopy, oligo-nucleotide synthesis and X-ray crystallography. A state-of-the-art imaging research center provides positron emission tomography, 3-D image processing, magnetic resonance imaging, computer graphics, spiral computed tomography, and radiopharmaceutical production.